Purpose : This study aims to develop an educational program tailored to healthcare-associated infection management to reduce the incidence of such infections, and to evaluate its effectiveness for intensive care unit nurses. Methods : A quasi-experimental study with a non-equivalent control group design was conducted, using pre-and- post-intervention data. A total of 54 participants were enrolled, with 27 in each group. The experimental group received an education program based on the ADDIE model, designed for healthcare-associated infection control, while the control group did not receive any relevant educational program. Results : When comparing healthcare-associated infection knowledge, awareness of infection control, and performance, the pre-and- post-program scores showed no statistically significant differences. However, for hand hygiene performance, the average score three months after the program was lower than before the program was implemented, but this difference was also not statistically significant. Conclusion : The findings suggest that more specific and long-term education, reflecting the realities and characteristics of clinical practice, is necessary. Continuous monitoring and feedback will be essential to improving the program's effectiveness.